| ncRNA name | hsa-miR-140-5p |
| ncRNA Category | miRNA |
| Disease name | retinoblastoma (RB) |
| Species | Homo sapiens |
| Tissues/Cell_line | RB samples, normal retinas; RB cell lines Y79, WERI-RB1, SO-Rb50 and HXO-RB44; human RPE cells |
| Methods | transfection, microarray, qPCR, CCK-8 assay, apoptosis analysis, cell cycle analysis, luciferase reporter assay, Western blot, immunohistochemistry |
| Expression pattern | down-regulated |
| Functional description | We found that a large set of miRNAs were ectopic expressions and miR-140-5p is most significantly down-regulated in human RB tissues compared with normal retinas. miR-140-5p may inhibit cell growth via blocking c-Met/AKT/mTOR signaling pathway. |
| PubMed ID | 30291212 |
| Year | 2018 |
| Title | MiR-140-5p suppresses retinoblastoma cell growth via inhibiting c-Met/AKT/mTOR pathway. |
| Drug-related ncRNA | NO |
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